Daousi C, MacFarlane I A, Woodward A, Nurmikko T J, Bundred P E, Benbow S J
Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK.
Diabet Med. 2004 Sep;21(9):976-82. doi: 10.1111/j.1464-5491.2004.01271.x.
A cross-sectional study has been performed in order to estimate the prevalence, severity, and current treatment of chronic painful peripheral neuropathy (CPPN) in people with diabetes in the community.
Using a structured questionnaire and examination we have assessed these factors in a community sample of people with diabetes (n=350) and compared them with 344 age- and sex-matched people without diabetes from the same locality.
The prevalence of CPPN was estimated to be 16.2%[95% confidence interval (CI): 6.8-16%] in people with diabetes compared with 4.9% (95% CI: 2.6-7.2%) in the control sample (P < 0.0001). Diabetic subjects with and without CPPN did not differ in age, sex, type and duration of diabetes, body mass index, smoking status and glycaemic control. However, CPPN diabetic subjects had significantly higher Visual Analogue Scale (VAS) scores for pain over the preceding 24 h [median (interquartile range) 3.5 (1.5-6.7) cm vs. 0.7 (0-3.9) cm, P < 0.0001]. Also, the total McGill Pain Questionnaire Score (a measure of pain quality and severity) was 18 (13-31.5) vs. 10 (4-16) (P < 0.0001). Of patients with diabetes and CPPN, 12.5% (7/56) had never reported their symptoms to their treating physician and 39.3% (22/56) had never received any treatment for their painful symptoms.
CPPN is common, often severe but frequently unreported and inadequately treated.
开展一项横断面研究，以评估社区糖尿病患者中慢性疼痛性周围神经病变（CPPN）的患病率、严重程度及当前治疗情况。
我们使用结构化问卷和检查，对社区中350名糖尿病患者样本的这些因素进行了评估，并将其与来自同一地区的344名年龄和性别匹配的非糖尿病患者进行比较。
糖尿病患者中CPPN的患病率估计为16.2%[95%置信区间（CI）：6.8 - 16%]，而对照样本中的患病率为4.9%（95%CI：2.6 - 7.2%）（P < 0.0001）。有和没有CPPN的糖尿病患者在年龄、性别、糖尿病类型和病程、体重指数、吸烟状况及血糖控制方面无差异。然而，患有CPPN的糖尿病患者在前24小时的视觉模拟评分（VAS）疼痛得分显著更高[中位数（四分位间距）3.5（1.5 - 6.7）厘米对0.7（0 - 3.9）厘米，P < 0.0001]。此外，麦吉尔疼痛问卷总评分（一种衡量疼痛性质和严重程度的指标）为18（13 - 31.5）对10（4 - 16）（P < 0.0001）。在患有糖尿病和CPPN的患者中，12.5%（7/56）从未向其治疗医生报告过症状，39.3%（22/56）从未因疼痛症状接受过任何治疗。
CPPN很常见，通常较为严重，但常常未被报告且治疗不足。
