Zhang Boyu, Jia Yanbin, Yuan Yanbo, Yu Xin, Xu Qi, Shen Yucun, Shen Yan
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Psychiatr Genet. 2004 Sep;14(3):161-3. doi: 10.1097/00041444-200409000-00008.
Several lines of evidence suggest that dysfunctions of neurotransmitters are associated with schizophrenia. DOPA decarboxylase (DDC) is an enzyme involved directly in the synthesis of dopamine and serotonin, and indirectly in the synthesis of noradrenaline. Therefore, the DDC gene can be considered a candidate gene for schizophrenia. We performed an association study between three single nucleotide polymorphisms in the DDC gene and paranoid schizophrenia. However, in our study no significant differences were found in the genotype distributions and allele frequencies between 80 paranoid schizophrenics and 108 controls for any of the polymorphisms. Neither did the haplotypes of the single nucleotide polymorphisms show any association with paranoid schizophrenia. Therefore, we conclude that the polymorphisms studied do not play a major role in paranoid schizophrenia pathogenesis in the population investigated.
多条证据表明，神经递质功能障碍与精神分裂症有关。多巴脱羧酶（DDC）是一种直接参与多巴胺和5-羟色胺合成、间接参与去甲肾上腺素合成的酶。因此，DDC基因可被视为精神分裂症的一个候选基因。我们对该DDC基因中的三个单核苷酸多态性与偏执型精神分裂症进行了关联研究。然而，在我们的研究中，80例偏执型精神分裂症患者和108例对照之间，任何一种多态性的基因型分布和等位基因频率均未发现显著差异。单核苷酸多态性的单倍型也未显示与偏执型精神分裂症有任何关联。因此，我们得出结论，在所研究的人群中，这些多态性在偏执型精神分裂症的发病机制中不发挥主要作用。
