Meng Junwei, Shi Yongyong, Zhao Xinzhi, Zhou Jian, Zheng Yonglan, Tang Ruqi, Ma Gang, Zhu Xuming, He Zangdong, Wang Zhe, Xu Yifeng, Feng Guoyin, He Lin
Bio-X Center, Shanghai Jiao Tong University, Haoran Building, 1954 Huashan Road, Shanghai 200030, PR China.
J Psychiatr Res. 2008 Apr;42(5):365-70. doi: 10.1016/j.jpsychires.2007.01.005. Epub 2007 Mar 26.
The GSK-3 beta gene encodes a protein kinase which is abundant in the brain, and its product is involved in signal transduction cascades of neuronal cell development, energy metabolism and body pattern formation. Previous studies have suggested that GSK-3 beta might act as a potential candidate locus for schizophrenia susceptibility. We genotyped six SNPs within the gene and conducted a case-control study involving 329 schizophrenic patients and 288 healthy subjects in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in the subtype of paranoid schizophrenic patients as well as schizophrenic subjects in general. Our results fail to replicate the association of the GSK-3 beta gene with susceptibility to schizophrenia in the Chinese population.
糖原合成酶激酶-3β（GSK-3β）基因编码一种在大脑中含量丰富的蛋白激酶，其产物参与神经元细胞发育、能量代谢和体型形成的信号转导级联反应。先前的研究表明，GSK-3β可能是精神分裂症易感性的一个潜在候选基因座。我们对该基因内的六个单核苷酸多态性（SNP）进行了基因分型，并在中国人群中开展了一项病例对照研究，涉及329例精神分裂症患者和288名健康受试者。我们检测了偏执型精神分裂症患者亚型以及一般精神分裂症患者的等位基因和基因型频率及单倍型分布。我们的结果未能在中国人群中重复证实GSK-3β基因与精神分裂症易感性之间的关联。
