[局限诺卡氏菌突变体中类固醇的生物转化]
[Bioconversion of steroids in mutants of Nocardia restrictus].
作者信息
Miclo A, Germain P
出版信息
C R Seances Soc Biol Fil. 1978;172(3):534-41.
PMID:153186
Abstract
Nocardia restrictus grows quickly on synthetic media containing different carbonated substrates (steroids, organic acids). The control of growth parameters of this microbial species allowed the development of the production and selection methodology for mutants unable to grow on androst-4ène-3,17-dione. A stable mutant convert androst-4-ène-3,17-dione in perhydroindan propionic acid without addition of any degradation inhibitor in the medium.
摘要
受限诺卡氏菌在含有不同含碳底物（类固醇、有机酸）的合成培养基上生长迅速。对该微生物物种生长参数的控制使得能够开发出针对无法在雄甾-4-烯-3,17-二酮上生长的突变体的生产和筛选方法。一种稳定的突变体在不向培养基中添加任何降解抑制剂的情况下，可将雄甾-4-烯-3,17-二酮转化为全氢茚丙酸。
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