Schäppi Michela G, Roulet Michel, Rochat Thierry, Belli Dominique C
Department of Pediatrics, HUG, Faculty of Medicine, Geneva, Switzerland.
J Pediatr Gastroenterol Nutr. 2004 Sep;39(3):253-6. doi: 10.1097/00005176-200409000-00005.
Cystic fibrosis patients have a wide spectrum of gastrointestinal disorders. The aim of this study was to investigate the function of gastroenteric neuromusculature and its response to a prokinetic.
14 CF children aged 8.6 + 1.3 years were studied by electrogastrography and compared to 10 age-matched controls. A second recording was performed in CF patients after administration of cisapride (0.3 mg/kg). Parameters analyzed were percentage of normal gastric rhythm (2.0 to 4.0 cpm), percentage of tachygastria (4.0 to 9.0 cpm), dominant frequency instability coefficient and power ratio.
CF and control groups were not different in age, height or weight. A significant post-prandial increase in percentage of tachygastria (26.7 + 4.5 versus 12.4 + 2.6; P < 0.05) was seen in CF patients, which was not corrected by cisapride. The power ratio showed a statistical increase in 3 cpm (3.7 + 0.8 versus 1.6 + 0.3; P < 0.05) and in tachygastria (5.3 + 1.2 versus 1.7 + 0.4; P < 0.03) in CF compared with controls. Cisapride had an effect on tachygastria power ratio (3.0 + 0.5; P < 0.04). Analysis of normal rhythm and the dominant frequency instability coefficient were not statistically different in CF and controls.
This study provides evidence of gastric dysmotility in CF patients.
囊性纤维化患者存在广泛的胃肠道疾病。本研究旨在调查胃肠神经肌肉系统的功能及其对促动力药的反应。
对14名年龄为8.6±1.3岁的囊性纤维化儿童进行胃电图检查，并与10名年龄匹配的对照组儿童进行比较。囊性纤维化患者在服用西沙必利（0.3mg/kg）后进行第二次记录。分析的参数包括正常胃节律百分比（2.0至4.0次/分钟）、快速胃动百分比（4.0至9.0次/分钟）、主导频率不稳定系数和功率比。
囊性纤维化组和对照组在年龄、身高或体重方面无差异。囊性纤维化患者餐后快速胃动百分比显著增加（26.7±4.5对12.4±2.6；P<0.05），西沙必利未能纠正这一情况。与对照组相比，囊性纤维化患者的功率比在3次/分钟时统计学上增加（3.7±0.8对1.6±0.3；P<0.05），在快速胃动时也增加（5.3±1.2对1.7±0.4；P<0.03）。西沙必利对快速胃动功率比有影响（3.0±0.5；P<0.04）。囊性纤维化患者与对照组在正常节律分析和主导频率不稳定系数方面无统计学差异。
本研究提供了囊性纤维化患者胃动力障碍的证据。
