Bentur Lea, Hino Bayan, Shamir Raanan, Elias Nael, Hartman Corina, Eshach-Adiv Orly, Berkowitz Drora
Pediatric Pulmonary Unit, Meyer Children's Hospital of Haifa, Rambam Medical Center, POB 9602, Haifa 31096, Israel.
J Cyst Fibros. 2006 Aug;5(3):187-91. doi: 10.1016/j.jcf.2006.03.003. Epub 2006 Apr 19.
Cystic fibrosis (CF) is frequently associated with gastrointestinal complaints that can be due to gastrointestinal dysmotility. Electrogastrography (EGG) is an attractive, non-invasive procedure to assess gastric electric activity. The aims of our study were to investigate EGG abnormalities in pancreatic sufficient and pancreatic insufficient CF patients, and to examine whether EGG correlates with gastric emptying as assessed by scintigraphy.
EGG was performed in 23 CF patients (12 pancreatic sufficient patients, 11 pancreatic insuffficient) by using cutaneous recording pre- and postprandialy. Pre- and postpostprandial EGG indexes were compared to 19 healthy control patients. Gastric emptying was assessed simultaneously by gastric scintigraphy in 11 of the 23 CF patients. Six patients underwent a repeated scintigraphy recording following a month of treatment with cisapride.
Abnormal patterns of EGG were found in 78.3% of CF patients compared to 31.3% of controls during fasting (p<or=0.003) and in 56.5% of CF patients compared to 15.7% in healthy controls postprandially (p<or=0.018). In the CF patients, dysmotility consisted mostly of bradygastria during both fasting (16 of 18 with abnormal EGG) and postprandially (12 of 13 [92.3%]). Gastric emptying results on scintigraphy were in agreement with EGG results in 9 of 11 (two normal and seven pathological). Five of the six patients treated with cisapride (83.3%) showed significant improvement in EGG indexes.
Our results suggest that EGG abnormalities are frequently found in CF patients. The similar rate of EGG and gastric scintigraphy abnormalities suggests that EGG may be a useful clinical tool in CF patients.
囊性纤维化（CF）常伴有胃肠道不适，这可能是由于胃肠动力障碍所致。胃电图（EGG）是一种用于评估胃电活动的、具有吸引力的非侵入性检查方法。我们研究的目的是调查胰腺功能正常和胰腺功能不全的CF患者的EGG异常情况，并通过闪烁扫描评估EGG是否与胃排空相关。
对23例CF患者（12例胰腺功能正常患者，11例胰腺功能不全患者）进行EGG检查，采用皮肤电极记录空腹及餐后情况。将空腹及餐后EGG指标与19例健康对照患者进行比较。23例CF患者中的11例同时通过胃闪烁扫描评估胃排空情况。6例患者在接受西沙必利治疗1个月后进行了重复闪烁扫描记录。
与对照组相比，CF患者在空腹时EGG异常模式的发生率为78.3%，而对照组为31.3%（p≤0.003）；餐后CF患者EGG异常模式的发生率为56.5%，而健康对照组为15.7%（p≤0.018）。在CF患者中,无论是空腹（18例EGG异常患者中的16例）还是餐后（13例中的12例[92.3%]），动力障碍主要表现为胃动过缓。闪烁扫描的胃排空结果与11例中的9例（2例正常，7例异常）的EGG结果一致。接受西沙必利治疗的6例患者中有5例（83.3%）的EGG指标有显著改善。
我们的结果表明，CF患者中经常发现EGG异常。EGG异常率与胃闪烁扫描异常率相似，提示EGG可能是CF患者有用的临床检查手段。
