Riezzo G, Cucchiara S, Chiloiro M, Minella R, Guerra V, Giorgio I
Laboratory of Experimental Pathophysiology, Scientific Institute of Gastroenterology, Castellana, Grotte Bari, Italy.
Dig Dis Sci. 1995 Jul;40(7):1428-34. doi: 10.1007/BF02285188.
We examined the effect of oral cisapride on gastric emptying time and myoelectrical activity using real-time ultrasonography and cutaneous electrogastrography in 10 children with nonulcer dyspepsia. A clear dominant frequency close to 3 cpm was present both at baseline and after eight weeks of cisapride. After cisapride, nine children had an increase in the normal slow wave percentage and the mean percentage of normal slow wave was significantly different (71.90 +/- 5.19% vs 79.16 +/- 5.54%; P < 0.01). Moreover, an increased stability of the dominant frequency, determined by computing the coefficient of variation before and after cisapride, was found (28.12 +/- 1.72% vs 23.61 +/- 3.47%; P < 0.01). At baseline the gastric emptying time, expressed as T1/2, was 139.76 +/- 40.04 min and at eight weeks 119.76 +/- 30.04 min (P = 0.06). As regards the relationship between EGG and gastric emptying, the proportion of children with improved normal slow wave percentage was similar to that with improved T1/2 emptying (Z = 0.57, P = 0.57). Thus, gastric electrical activity seems to be an important factor in the pathophysiology of nonulcer dyspepsia in children.
我们采用实时超声检查和皮肤胃电图检查，对10例非溃疡性消化不良患儿口服西沙必利后胃排空时间和肌电活动的影响进行了研究。西沙必利治疗前及治疗8周后均出现接近3次/分钟的明显优势频率。西沙必利治疗后，9例患儿正常慢波百分比增加，正常慢波平均百分比有显著差异（71.90±5.19% 对79.16±5.54%；P<0.01）。此外，通过计算西沙必利治疗前后的变异系数发现优势频率稳定性增加（28.12±1.72% 对23.61±3.47%；P<0.01）。治疗前胃排空时间（以T1/2表示）为139.76±40.04分钟，治疗8周后为119.76±30.04分钟（P=0.06）。关于胃电图与胃排空之间的关系，正常慢波百分比改善的患儿比例与T1/2排空改善的患儿比例相似（Z=0.57，P=0.57）。因此，胃电活动似乎是儿童非溃疡性消化不良病理生理学中的一个重要因素。
