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使用低剂量布比卡因/阿片类药物硬膜外输注是否会提高正常分娩率?

Does the use of low dose bupivacaine/opioid epidural infusion increase the normal delivery rate?

作者信息

Reynolds F, Russell R, Porter J, Smeeton N

机构信息

Department of Anaesthesia, St. Thomas' Hospital, London, UK.

出版信息

Int J Obstet Anesth. 2003 Jul;12(3):156-63. doi: 10.1016/S0959-289X(03)00008-6.

Abstract

To investigate whether using low dose epidural infusion improves the normal delivery rate, outcome of labour was studied in women with singleton vertex presentations randomised to receive either 0.0625% bupivacaine opioid, or plain bupivacaine 0.125% for labour. The infusion rate was titrated to maintain analgesia and a sensory level to T10. Data were analysed using the unpaired t test, Mann-Whitney U test and for categorical variables chi2 test. Adjusted odds ratios for factors significantly associated with non-normal delivery were calculated using stepwise logistic regression. There were 291 women in the low dose and 296 in the plain bupivacaine group. There were no significant differences between groups in parity, race, induction of labour, use of augmentation, cervical dilatation at epidural insertion, duration of any stage of labour or duration or volume of infusion. Total dose of bupivacaine (126 +/- 47 mg versus 91 +/- 32 mg) and the proportion of women with motor block at the end of labour (45% versus 27%) were significantly greater in the plain bupivacaine than in the low dose group (P < 0.0001). The adjusted odds ratios (95% CI) for factors significantly associated with non-normal delivery were primiparity: 4.68 (2.78-7.88), older maternal age: 1.1 (1.05-1.14), longer active second stage of labour: 1.01 (1.005-1.017), total bupivacaine dose: 1.01 (1.005-1.016) and greater cervical dilatation at epidural insertion 1.22 (1.08-1.37). Treatment group and motor block at the end of labour had no significant effect. We found no increase in normal delivery rate with low dose infusions.

摘要

为研究低剂量硬膜外输注是否能提高顺产率,我们对单胎头位产妇进行了研究,将其随机分为两组,一组接受0.0625%布比卡因阿片类药物,另一组接受0.125%普通布比卡因用于分娩。输注速率根据镇痛效果和T10感觉平面进行调整。数据采用非配对t检验、曼-惠特尼U检验进行分析,分类变量采用卡方检验。使用逐步逻辑回归计算与非顺产显著相关因素的调整比值比。低剂量组有291名女性,普通布比卡因组有296名女性。两组在产次、种族、引产、催产使用、硬膜外穿刺时宫颈扩张程度、任何产程阶段的持续时间或输注持续时间及量方面均无显著差异。普通布比卡因组的布比卡因总剂量(126±47mg对91±32mg)和分娩结束时出现运动阻滞的女性比例(45%对27%)均显著高于低剂量组(P<0.0001)。与非顺产显著相关因素的调整比值比(95%CI)为:初产:4.68(2.78 - 7.88),产妇年龄较大:1.1(1.05 - 1.14),活跃第二产程较长:1.01(1.005 - 1.017),布比卡因总剂量:1.01(1.005 - 1.016),硬膜外穿刺时宫颈扩张较大:1.22(1.08 - 1.37)。治疗组和分娩结束时的运动阻滞无显著影响。我们发现低剂量输注并未提高顺产率。

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