Chiles Thomas C
Department of Biology, Boston College, Chestnut Hill, MA 02467, USA.
J Immunol. 2004 Sep 1;173(5):2901-7. doi: 10.4049/jimmunol.173.5.2901.
Abs produced by B lymphocytes play an essential role in humoral immunity against pathogens. This response is dependent upon the extent of genome replication, which in turn allows clonal expansion of Ag-specific B cell precursors. Thus, there is considerable interest in understanding how naive B cells commit to genome replication following Ag challenge. The BCR is a key regulator of B cell growth responses in the bone marrow and the periphery. The importance of identifying BCR-coupled signaling networks and their cell cycle targets is underscored by the recognition that aberrant cell cycle control can lead to lymphoproliferative disorders or lymphoid malignancies. This review focuses on recent progress toward understanding the function of cyclin D2 in cell cycle control, and in the development of murine B lymphocytes.
B淋巴细胞产生的抗体在针对病原体的体液免疫中发挥着至关重要的作用。这种反应取决于基因组复制的程度，而基因组复制反过来又允许抗原特异性B细胞前体进行克隆扩增。因此，人们对了解初始B细胞在抗原刺激后如何进行基因组复制有着浓厚的兴趣。BCR是骨髓和外周中B细胞生长反应的关键调节因子。认识到异常的细胞周期控制可导致淋巴细胞增殖性疾病或淋巴恶性肿瘤，凸显了识别与BCR偶联的信号网络及其细胞周期靶点的重要性。本综述着重介绍了在理解细胞周期蛋白D2在细胞周期控制以及小鼠B淋巴细胞发育中的功能方面的最新进展。
