Bierhaus A, Humpert P M, Nawroth P P
Pediatr Nephrol. 2004 Nov;19(11):1189-91. doi: 10.1007/s00467-004-1603-0. Epub 2004 Aug 20.
It is well accepted that psychosocial stress contributes to the pathogenesis of hypertension, cardiovascular disease, and renal disease. Although even lay persons are aware that stress can be dangerous to health, the molecular mechanisms by which psychosocial events contribute to cellular dysfunction have hitherto been poorly understood by scientists. The pro-inflammatory transcription factor NF-kappaB has recently been identified as a potential critical bridge between stress and cellular activation. NF-kappaB activation, in turn, is known to play a pivotal role in vascular and renal disease. Activation of NF-kappaB, evoked by psychosocial stress, may directly target vessels and kidneys and thus represent an additional risk factor for cardiovascular and renal disease.
社会心理应激会导致高血压、心血管疾病和肾脏疾病的发病，这一点已得到广泛认可。尽管即使是外行人也知道压力对健康有害，但迄今为止，科学家们对社会心理事件导致细胞功能障碍的分子机制仍知之甚少。促炎转录因子核因子κB（NF-κB）最近被确定为压力与细胞激活之间潜在的关键桥梁。反过来，已知NF-κB激活在血管和肾脏疾病中起关键作用。社会心理应激引起的NF-κB激活可能直接作用于血管和肾脏，因此是心血管和肾脏疾病的另一个危险因素。
