Sarkar Fazlul H, Li Yiwei, Wang Zhiwei, Kong Dejuan
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Int Rev Immunol. 2008;27(5):293-319. doi: 10.1080/08830180802276179.
The nuclear factor-kappaB (NF-kappaB) pathway is one of the most important cellular signal transduction pathways involved in both physiologic processes and disease conditions. It plays important roles in the control of immune function, inflammation, stress response, differentiation, apoptosis, and cell survival. Moreover, NF-kappaB is critically involved in the processes of development and progression of cancers. More importantly, recent studies have shown that NF-kappaB signaling also plays critical roles in the epithelial-mesenchymal transition (EMT) and cancer stem cells. Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases.
核因子-κB（NF-κB）信号通路是参与生理过程和疾病状态的最重要的细胞信号转导通路之一。它在免疫功能调控、炎症、应激反应、分化、凋亡及细胞存活中发挥重要作用。此外，NF-κB在癌症的发生发展过程中也起着关键作用。更重要的是，最近的研究表明，NF-κB信号传导在上皮-间质转化（EMT）和癌症干细胞中也发挥着关键作用。因此，靶向NF-κB信号通路可能是预防和/或治疗人类癌症及炎症性疾病的有效策略。
