Cléroux J, Yardley C, Marshall A, Coulombe D, Lacourcière Y
Hypertension Research Unit, CHUL Research Center, Canada.
Am J Hypertens. 1992 Feb;5(2):84-7. doi: 10.1093/ajh/5.2.84.
In a randomized, double-blind, placebo-controlled, crossover study with two 4-week treatment periods, we investigated the effects of calcium channel blockade with 5 mg slow release oral isradipine on postexercise blood pressure and systemic hemodynamics (echocardiography) in ten hypertensive patients. The results show that the combination of exercise and isradipine treatment exerts additive antihypertensive effects in hypertensive patients after exercise. The antihypertensive effect of prior exercise with placebo was related to a significant fall in total peripheral resistance. After exercise during isradipine treatment, total peripheral resistance was lower than with placebo. Thus, isradipine exerts an additional antihypertensive effect during the postexercise period, which appears to be mediated by a further reduction of total peripheral resistance.
在一项有两个4周治疗期的随机、双盲、安慰剂对照、交叉研究中，我们调查了10名高血压患者口服5毫克缓释伊拉地平进行钙通道阻滞对运动后血压和全身血流动力学（超声心动图）的影响。结果表明，运动与伊拉地平治疗相结合对运动后的高血压患者具有相加的降压作用。运动加安慰剂治疗的降压作用与总外周阻力显著下降有关。在伊拉地平治疗期间运动后，总外周阻力低于安慰剂组。因此，伊拉地平在运动后阶段发挥额外的降压作用，这似乎是由总外周阻力的进一步降低介导的。
