Cléroux J, Kouamé N, Yardley C, Marshall A, Lacourcière Y
Hypertension Research Unit, Le Centre Hospitalier de l'Université Laval (CHUL) Research Center, Québec, Canada.
J Cardiovasc Pharmacol. 1992;19 Suppl 3:S66-9.
In untreated hypertensive patients, blood pressure is decreased during the hours that follow a single bout of exercise, but the mechanisms involved are as yet unknown. As antihypertensive chemotherapy may interfere with cardiovascular regulation, we investigated the effects of calcium antagonism with isradipine (slow-release oral formulation, SRO) on postexercise blood pressure and on the reflex control of forearm vascular resistance in patients with mild-to-moderate hypertension. The results show that isradipine SRO exerted an additional blood pressure-lowering effect after exercise that was associated with a further decrease in forearm vascular resistance. The reflex changes in forearm vascular resistance were potentiated after exercise, but were not further affected by isradipine SRO. Therefore, isradipine SRO does not interfere with the cardiovascular mechanisms that act to decrease blood pressure after exercise in patients who have hypertension.
在未经治疗的高血压患者中，单次运动后的数小时内血压会下降，但其涉及的机制尚不清楚。由于抗高血压化疗可能会干扰心血管调节，我们研究了使用伊拉地平（缓释口服制剂，SRO）进行钙拮抗对轻至中度高血压患者运动后血压及前臂血管阻力反射性控制的影响。结果显示，伊拉地平SRO在运动后发挥了额外的降压作用，这与前臂血管阻力的进一步降低有关。运动后前臂血管阻力的反射性变化增强，但未受到伊拉地平SRO的进一步影响。因此，伊拉地平SRO不会干扰高血压患者运动后降低血压的心血管机制。
