锂对大鼠血清及组织中钙和镁稳态的影响。

The influence of lithium on calcium and magnesium homeostasis in serum and tissues of rats.

作者信息

Kiełczykowska Małgorzata, Pasternak Kazimierz, Musik Irena

机构信息

Department of General Chemistry, Medical University of Lublin.

出版信息

Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):281-4.

PMID:15323205

Abstract

Lithium is used in medicine. However, its administration can have negative side effects, disturb the water-electrolyte equilibrium and affect the level of essential elements. For these reasons the influence of oral lithium intoxication at the dose of 150 mg Li dm(-3) on magnesium and calcium levels in serum and tissues of rats was investigated. The concentration of Mg and Ca in serum increased throughout the experiment. The concentration of magnesium in tissues decreased after three weeks in liver, kidney, brain and femoral muscle. The trend of the changes of calcium tissue concentration was opposite to the one observed in the case of magnesium.

摘要

锂被用于医学领域。然而，其给药可能会产生负面副作用，扰乱水电解质平衡并影响必需元素的水平。基于这些原因，研究了口服150毫克锂/立方分米剂量的锂中毒对大鼠血清和组织中镁和钙水平的影响。在整个实验过程中，血清中镁和钙的浓度均升高。在肝脏、肾脏、大脑和股四头肌中，三周后组织中的镁浓度降低。钙组织浓度的变化趋势与镁的情况相反。