Mancini A, di Pietro C, de Marinis L, Rossi S, Lombardi C P, Iacona T, Bellantone R, Liberale I, Menini E, Crucitti F
Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy.
Cancer Detect Prev. 1992;16(1):27-30.
We studied 39 women with benign breast disease in order to evaluate their endocrine status. Two groups of women were distinguished: premenopausal (n = 22) and postmenopausal (n = 17). We determined basal concentrations of the following: follicle-stimulating (FSH) hormones, luteinizing hormone (LH), prolactin (PRL), estrone (E1), estradiol (E2), testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS). We also assayed sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). The samples in premenopausal subjects were collected in the follicular phase. There was no significant difference between the groups considered and normal control subjects for any of the hormones tested; there was no significant correlation between T concentration or E2/T ratios and SHBG levels; the FAI was not significantly different compared to normal subjects. In conclusion, even if basal steroid, gonadotropin, and SHBG levels do not indicate an unequivocal alteration, it is not possible to exclude subtle alterations in transport and local metabolism of steroids. The balance between steroids and SHBG seems to indicate small dysregulations, which could be of some importance.
我们研究了39例患有良性乳腺疾病的女性，以评估她们的内分泌状况。区分出两组女性：绝经前（n = 22）和绝经后（n = 17）。我们测定了以下各项的基础浓度：促卵泡激素（FSH）、黄体生成素（LH）、催乳素（PRL）、雌酮（E1）、雌二醇（E2）、睾酮（T）、雄烯二酮（A）、硫酸脱氢表雄酮（DHEAS）。我们还检测了性激素结合球蛋白（SHBG）并计算了游离雄激素指数（FAI）。绝经前受试者的样本在卵泡期采集。在所检测的任何一种激素方面，所研究的组与正常对照受试者之间均无显著差异；T浓度或E2/T比值与SHBG水平之间无显著相关性；与正常受试者相比，FAI无显著差异。总之，即使基础类固醇、促性腺激素和SHBG水平未显示明确改变，但仍无法排除类固醇在转运和局部代谢方面的细微改变。类固醇与SHBG之间的平衡似乎表明存在小的调节异常，这可能具有一定重要性。
