Buchan T, Page J D, Gandah P, Slaven J P, Hudson G J
S Afr Med J. 1977 Feb 19;51(8):237-40.
Forty Black men diagnosed as schizophrenic and admitted to Ingutsheni Hospital during a period of 3 months, were allocated alternately to treatment with either clothiapine or chlorpromazine. Six patients were excluded from the trial because of an incorrect diagnosis and 34, 17 in each group, completed the trial. The 2 groups were comparable for both severity and symptoms of their illnesses. Degrees of regression of psychotic symptoms as assessed by the Brief Psychiatric Rating Scale, were comparable for the 2 groups. Adverse effects were not troublesome with clothiapine and there was no evidence of disturbed liver function, but haemoglobin values and white cell counts were sometimes decreased. EEG studies showed that clothiapine produced an increase in the slow activity but no paroxysmal acitvity. It was concluded that clothiapine is a valuable drug for the management of actue schizophrenia.
在3个月的时间里，40名被诊断为精神分裂症并入住英古申尼医院的黑人男性被交替分配接受氯氮平或氯丙嗪治疗。6名患者因诊断错误被排除在试验之外，34名患者（每组17名）完成了试验。两组患者疾病的严重程度和症状具有可比性。通过简明精神病评定量表评估，两组患者精神病症状的缓解程度相当。氯氮平的不良反应不严重，没有肝功能紊乱的证据，但血红蛋白值和白细胞计数有时会降低。脑电图研究表明，氯氮平会使慢波活动增加，但不会产生阵发性活动。得出的结论是，氯氮平是治疗急性精神分裂症的一种有价值的药物。
