硫代噻吨与三氟拉嗪/氯丙嗪复合物治疗慢性精神分裂症的双盲比较
A double blind comparison of thiothixene and a trifluoperazine/chlorpromazine composite in the treatment of chronic schizophrenia.
作者信息
Knight R G, Harrison A
出版信息
N Z Med J. 1979 Apr 25;89(634):302-4.
PMID:377155
Abstract
Thirty chronic schizophrenic patients participated in a double-blind crossover trial of thiothixene (Navane) and a control drug combination of trifluoperazine and chlorpromazine. No statistically significant difference was found between the two drug conditions on numerous behavioural scales. Experience with thiothixene suggested that it was comparable with control drugs in the activation of withdrawn patients but needs to be used in combination with a more sedative antipsychotic agent in the treatment of some paranoid patients.
摘要
30名慢性精神分裂症患者参与了硫利达嗪（甲硫达嗪）与三氟拉嗪和氯丙嗪对照药物组合的双盲交叉试验。在众多行为量表上，两种药物状况之间未发现统计学上的显著差异。硫利达嗪的使用经验表明，在激活退缩患者方面它与对照药物相当，但在治疗一些偏执型患者时需要与更具镇静作用的抗精神病药物联合使用。
相似文献
1
A double blind comparison of thiothixene and a trifluoperazine/chlorpromazine composite in the treatment of chronic schizophrenia.
N Z Med J. 1979 Apr 25;89(634):302-4.
2
Proceedings: A comparative study of thiothixene and chlorpromazine in chronic schizophrenic patients: application of a special psychometric test battery.
Psychopharmacol Bull. 1976 Jan;12(1):38-9.
3
A comparison of thiothixene with chlorpromazine in the treatment of mania.
J Clin Psychopharmacol. 1988 Feb;8(1):33-7.
4
The assessment of thiothixene in chronic schizophrenia. A double-blind controlled trial.
Dis Nerv Syst. 1975 Nov;36(11):625-9.
5
Double-blind trial of thiothixene and chlorpromazine in acute schizophrenia.
Int Pharmacopsychiatry. 1978;13(1):50-7. doi: 10.1159/000468321.
6
Comprehesiven clinical studies with thiothixene.
Dis Nerv Syst. 1975 Sep;36(9):473-7.
7
Psychopharmacological correlates of post-psychotic depression: a double-blind investigation of haloperidol vs thiothixene in outpatient schizophrenia.
J Clin Psychiatry. 1982 Mar;43(3):105-10.
8
Comparison of efficacy of zotepine and thiothixene in schizophrenia in a double-blind study.
Pharmacopsychiatry. 1987 Feb;20(1 Spec No):38-46. doi: 10.1055/s-2007-1017128.
9
Are antipsychotic drugs interchangeable?
J Nerv Ment Dis. 1974 Nov;159(5):343-8. doi: 10.1097/00005053-197411000-00004.
10
Thiothixene and trifluoperazine in acutely disturbed schizophrenic patients.
J Pak Med Assoc. 1977 Apr;27(4):313-6.
引用本文的文献
1
Cessation of medication for people with schizophrenia already stable on chlorpromazine.
Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD006329. doi: 10.1002/14651858.CD006329.
2
Trifluoperazine for schizophrenia.
Cochrane Database Syst Rev. 2004;2004(1):CD003545. doi: 10.1002/14651858.CD003545.pub2.
Zotero 插件