Park Joon Hyuk, Yang Hyun Ju, Park Suyeon, Kim Bong Soo
Department of Psychiatry, Jeju National University School of Medicine, Jeju, Korea.
Department of Psychiatry, Jeju National University Hospital, Jeju, Korea.
J Korean Med Sci. 2025 Aug 25;40(33):e200. doi: 10.3346/jkms.2025.40.e200.
The motoric cognitive risk syndrome (MCRS) is characterized by slow gait and cognitive complaints. A motor-based approach to MCRS provides a clinical strategy for identifying individuals at high risk for dementia.
This study included 81 outpatients with mild cognitive impairment (MCI). All participants underwent clinical evaluations, including volumetric brain magnetic resonance imaging (MRI) and neuropsychological testing with the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet. White matter hyperintensities (WMH) volume was calculated using automated segmentation analysis from three-dimensional MRI images. MCRS was defined by the presence of cognitive complaints and slow gait defined as gait speed at least one standard deviation below age- and sex-specific means.
A total of 31 subjects with MCRS and 50 subjects without slow gait participated in this study. The linear regression analysis revealed a significant negative relationship between WMH volume and gait speed in both the MCI group with MCRS (β = -1.010, < 0.001) and the MCI group without slow gait (β = -0.427, = 0.016). Both age (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.02-1.34) and WMH volume (OR, 1.11; 95% CI, 1.01-1.22) were significantly associated with MCRS, even after adjusting for confounding factors. After applying Bonferroni correction ( < 0.0036), the MCRS group exhibited significantly worse performance on word list memory, word list recall, and MMSE-KC compared to the MCI group without slow gait.
MCRS represents a distinct and more severe clinical entity within the MCI population, characterized by greater cognitive impairment and increased WMH burden.
运动认知风险综合征（MCRS）的特征为步态缓慢和认知主诉。基于运动的MCRS研究方法为识别痴呆高危个体提供了一种临床策略。
本研究纳入了81例轻度认知障碍（MCI）门诊患者。所有参与者均接受了临床评估，包括容积性脑磁共振成像（MRI）以及使用韩国版阿尔茨海默病注册协会评估包进行神经心理学测试。白质高信号（WMH）体积通过三维MRI图像的自动分割分析计算得出。MCRS的定义为存在认知主诉且步态缓慢，步态缓慢定义为步态速度至少低于年龄和性别特异性均值一个标准差。
本研究共纳入了31例患有MCRS的受试者和50例步态不缓慢的受试者。线性回归分析显示，在患有MCRS的MCI组（β = -1.010，< 0.001）和步态不缓慢的MCI组中，WMH体积与步态速度之间均存在显著的负相关（β = -0.427，= 0.016）。即使在调整混杂因素后，年龄（比值比[OR]，1.17；95%置信区间[CI]，1.02 - 1.34）和WMH体积（OR，1.11；95%CI，1.01 - 1.22）均与MCRS显著相关。应用Bonferroni校正（< 0.0036）后，与步态不缓慢的MCI组相比，MCRS组在单词列表记忆、单词列表回忆和MMSE - KC方面的表现显著更差。
MCRS代表了MCI人群中一个独特且更严重的临床实体，其特征为认知障碍更严重且WMH负担增加。
