Eren F, Savci D, Erbarut I, Gökaslan H
Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
Cytopathology. 2004 Aug;15(4):195-9. doi: 10.1111/j.1365-2303.2004.00162.x.
In this study, we have investigated the frequency and clinical significance of glandular cells in posthysterectomy vaginal smears. The slides of vaginal cuff smears of 290 patients were reviewed. The glandular cells were categorized into three groups: (1) squamous metaplastic-like cells; (2) columnar endocervical-like cells; and (3) small round cuboidal cells. Glandular cells were found in 39 (13%) of the 290 vaginal smears. Group 1 type cells were seen in 76% (n = 30), group 2 type cells in 38% (n = 15) and group 3 type cells in 47% (n = 19) of the smears. In 19 (48%) of the smears combination of two or three groups were seen. The presence of glandular cells showed a strong association with inflammation/repair as a background finding in the smears. No correlation could be found between the presence of atrophy and history of chemotherapy or radiotherapy. Apart from these there was a prominent increase in reporting benign glandular cells after the application of the current Bethesda 2001 reporting criteria in our laboratory. As a result our study showed that the finding of glandular cells in posthysterectomy vaginal smears is more frequent than expected and most of them could be related to inflammatory and regenerative processes in the absence of a clearly identified underlying cause.
在本研究中，我们调查了子宫切除术后阴道涂片腺细胞的出现频率及其临床意义。对290例患者的阴道断端涂片玻片进行了复查。腺细胞分为三组：（1）鳞状化生样细胞；（2）柱状宫颈内膜样细胞；（3）小圆形立方形细胞。在290份阴道涂片中，39份（13%）发现有腺细胞。涂片中有76%（n = 30）可见第1组类型细胞，38%（n = 15）可见第2组类型细胞，47%（n = 19）可见第3组类型细胞。19份（48%）涂片可见两组或三组细胞并存。涂片背景中，腺细胞的出现与炎症/修复密切相关。萎缩的存在与化疗或放疗史之间未发现相关性。除此之外，在我们实验室应用现行的2001年贝塞斯达报告标准后，良性腺细胞的报告显著增加。因此，我们的研究表明，子宫切除术后阴道涂片中腺细胞的发现比预期更为频繁，且在没有明确潜在病因的情况下，大多数腺细胞可能与炎症和再生过程有关。
