Bengtsson G, Bryman I, Thorburn J, Lindblom B
Department of Obstetrics and Gynecology, University of Göteborg, Sahlgrenska Hospital, Sweden.
Obstet Gynecol. 1992 Apr;79(4):589-91.
The aim of this study was to evaluate the efficacy of methotrexate as second-line treatment for ectopic pregnancy. Oral methotrexate was used in 15 patients with evidence of persistent trophoblast after conservative laparoscopic surgery for tubal pregnancy. The treatment was successful in 14 of 15 cases, and the mean time for decline of serum hCG to nonpregnant levels was 24 days. In the remaining case, hCG continued to rise. Side effects were noticed, even at a low dosage, but only in those subjects not receiving citrovorum rescue. As an alternative to a second operation, oral methotrexate appears to be an effective and well-tolerated therapy for persistent trophoblast.
本研究的目的是评估甲氨蝶呤作为异位妊娠二线治疗方法的疗效。15例输卵管妊娠保守性腹腔镜手术后有持续性滋养层证据的患者使用了口服甲氨蝶呤。15例中有14例治疗成功，血清人绒毛膜促性腺激素（hCG）降至非妊娠水平的平均时间为24天。在其余1例中，hCG持续升高。即使是低剂量，也观察到了副作用，但仅在未接受亚叶酸救援的患者中出现。作为二次手术的替代方法，口服甲氨蝶呤似乎是治疗持续性滋养层的一种有效且耐受性良好的疗法。
