Hill G A, Cartwright P S, Herbert C M
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
J Reprod Med. 1990 Apr;35(4):415-7.
With the advent of conservative management of ectopic gestation, several patients have had persistent trophoblastic tissue after their surgical procedure. In the past such patients required repeat laparoscopy or laparotomy and further conservative or radical surgery. However, the use of methotrexate with leukovorum rescue offers a new alternative in the management of patients with persistent trophoblastic tissue after conservative surgery. Two patients with persistent trophoblastic tissue were treated successfully with methotrexate and leukovorum rescue. The use of medical therapy in such patients avoids a second surgical procedure, is associated with few side effects and appears to be an acceptable management alternative.
随着异位妊娠保守治疗方法的出现，一些患者在手术后仍有持续性滋养层组织。过去，这类患者需要再次进行腹腔镜检查或剖腹手术以及进一步的保守或根治性手术。然而，使用甲氨蝶呤并辅以亚叶酸解救为保守手术后有持续性滋养层组织的患者的治疗提供了一种新的选择。两名有持续性滋养层组织的患者通过甲氨蝶呤和亚叶酸解救治疗成功。在此类患者中使用药物治疗避免了二次手术，副作用少，似乎是一种可接受的治疗选择。
