Nosten François, Rogerson Stephen J, Beeson James G, McGready Rose, Mutabingwa Theonest K, Brabin Bernard
Shoklo Malaria Research Unit, 736/2 Intarakiri Road, PO Box 46, Mae Sot, 63110 Thailand.
Trends Parasitol. 2004 Sep;20(9):425-32. doi: 10.1016/j.pt.2004.06.007.
The increased susceptibility of pregnant women to malaria infection has long been recognized, but the magnitude of the disease burden in this particular group, together with the pathophysiology of maternal malaria and the specific difficulties in treatment, have only recently been the focus of research. Most research on maternal malaria has derived from sub-Saharan Africa where transmission is high, whereas most of the studies on the treatment of malaria and the effect of non-falciparum species has been conducted in low-transmission areas of Asia. In this paper, we attempt to improve our understanding of the disease and its mechanisms from observed differences and similarities between contrasting areas of transmission, and to identify priorities for future research.
孕妇对疟疾感染的易感性增加早已为人所知，但这一特定群体的疾病负担程度、孕产妇疟疾的病理生理学以及治疗中的具体困难，直到最近才成为研究的重点。大多数关于孕产妇疟疾的研究都来自撒哈拉以南非洲，那里的传播率很高，而大多数关于疟疾治疗和非恶性疟原虫种类影响的研究则是在亚洲的低传播地区进行的。在本文中，我们试图通过观察不同传播地区之间的差异和相似性，来加深对该疾病及其机制的理解，并确定未来研究的重点。
