Riley-Vargas Rebecca C, Gill Darcy B, Kemper Claudia, Liszewski M Kathryn, Atkinson John P
Washington University School of Medicine, Department of Medicine, Division of Rheumatology, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Trends Immunol. 2004 Sep;25(9):496-503. doi: 10.1016/j.it.2004.07.004.
During the 1980s CD46 was discovered in a search for C3b binding proteins of human peripheral blood cells. Its role as an inactivator of C3b and C4b deposited on self-tissue is highlighted by the observation that partial deficiency of CD46 is a predisposing factor to hemolytic uremic syndrome. This discovery has an impact on the treatment options for these patients. Other new findings have expanded the role of CD46 in immunity and disease. For example, signaling through CD46 on human T lymphocytes drives them to become regulatory cells, indicating a novel link between the complement system and cellular immunity. Also, CD46 interacts with at least seven human pathogens and participates in reproduction/fertilization, further suggesting that dissecting its multi-faceted activities will have important clinical implications.
在20世纪80年代，人们在寻找人类外周血细胞的C3b结合蛋白时发现了CD46。CD46作为沉积在自身组织上的C3b和C4b的灭活因子，其作用因以下观察结果而凸显：CD46部分缺乏是溶血性尿毒症综合征的一个易感因素。这一发现对这些患者的治疗选择产生了影响。其他新发现扩展了CD46在免疫和疾病中的作用。例如，人类T淋巴细胞上的CD46信号传导促使它们成为调节性细胞，这表明补体系统与细胞免疫之间存在新的联系。此外，CD46与至少七种人类病原体相互作用并参与生殖/受精，这进一步表明剖析其多方面的活性将具有重要的临床意义。
