Immune Signaling Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia.
FEBS Lett. 2010 Dec 15;584(24):4838-44. doi: 10.1016/j.febslet.2010.09.003. Epub 2010 Sep 7.
CD46 is a cell surface protein that regulates complement activity and is utilized as a receptor by numerous viral and bacterial pathogens that infect humans. CD46 is not just an entry site for pathogens, but can affect various cellular activities in response to pathogen binding that can have profound consequences for the host response to infection. The study of CD46 signaling in T cells has emerged as an exciting area of research that is shedding new light on how pathogens might manipulate the host immune response. This review will focus on our current understanding of CD46 signaling in T cell polarity and how this might influence disease outcome.
CD46 是一种细胞表面蛋白，可调节补体活性，并被多种感染人类的病毒和细菌病原体用作受体。CD46 不仅是病原体的进入部位，还可以响应病原体结合来影响各种细胞活动，这可能对宿主对感染的反应产生深远影响。T 细胞中 CD46 信号转导的研究已成为一个令人兴奋的研究领域，揭示了病原体如何操纵宿主免疫反应的新机制。本综述将重点介绍我们目前对 T 细胞极性中 CD46 信号转导的理解，以及这可能如何影响疾病结局。
