一些芳氧基/硫代芳氧基恶唑烷酮衍生物的合成及其抗菌活性
Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives.
作者信息
Arora Vishal, Salunkhe Manikrao M, Sinha Neelima, Sinha Rakesh K, Jain Sanjay
机构信息
Department of Chemistry, The Institute of Science, 15 Madam Cama Road, Mumbai 400 032, Maharashtra, India.
出版信息
Bioorg Med Chem Lett. 2004 Sep 20;14(18):4647-50. doi: 10.1016/j.bmcl.2004.06.096.
A series of aryloxy/thioaryloxy oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activity by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 12a, 12b, 14a, and 14b from this series were found to be equipotent or more potent than linezolid in vitro.
合成了一系列芳氧基/硫代芳氧基恶唑烷酮衍生物，并通过测定对一组敏感和耐药的革兰氏阳性及革兰氏阴性微生物的最低抑菌浓度（MIC）来测试其体外抗菌活性，其中一些微生物对甲氧西林和万古霉素耐药。发现该系列中的化合物12a、12b、14a和14b在体外与利奈唑胺等效或更具活性。
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