新型（未）取代苯并三唑基恶唑烷酮衍生物的合成及其抗菌活性
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives.
作者信息
Dixit Prasad P, Nair Prathap S, Patil Vijaykumar J, Jain Sanjay, Arora Sudershan K, Sinha Neelima
机构信息
Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46/47A, Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India.
出版信息
Bioorg Med Chem Lett. 2005 Jun 15;15(12):3002-5. doi: 10.1016/j.bmcl.2005.04.045.
A series of novel (un)substituted benzotriazolyl oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 20, 21, 24, 29 and 30 from this series were found to be equipotent or more potent than linezolid in vitro.
已经合成了一系列新型的（未）取代苯并三唑基恶唑烷酮衍生物，并通过针对一组敏感和耐药的革兰氏阳性和革兰氏阴性微生物测定最低抑菌浓度（MIC）来测试其体外抗菌活性，其中一些微生物对甲氧西林和万古霉素耐药。发现该系列中的化合物20、21、24、29和30在体外与利奈唑胺等效或更有效。
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