Zhao Zhenjiang, Xu Yufang, Qian Zhigang, Tian Wenhong, Qian Xuhong, Zhong Jian-Jiang
Shanghai Key Lab. of Chemical Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Bioorg Med Chem Lett. 2004 Sep 20;14(18):4755-8. doi: 10.1016/j.bmcl.2004.06.082.
To develop more effective abiotic elicitors for cell suspension cultures of T. chinensis to meet the needs for paclitaxel as anti-tumor drug, some fluoro- or hydroxyl-containing groups are introduced to the ester moiety of jasmonic acid by the esterification or acylation with bis(trichloromethyl) carbonate and corresponding alcohol. Some of them are found to be novel and effective elicitors, which can enhance the production of taxuyunnanine C (Tc) up to 60% more than that by methyl jasmonate (MJA) in T. chinensis cell cultures.
为开发更有效的用于中国红豆杉细胞悬浮培养的非生物诱导子，以满足作为抗肿瘤药物的紫杉醇的需求，通过用双（三氯甲基）碳酸酯与相应的醇进行酯化或酰化反应，将一些含氟或含羟基的基团引入茉莉酸的酯部分。发现其中一些是新型且有效的诱导子，它们能使中国红豆杉细胞培养物中云南紫杉碱C（Tc）的产量比茉莉酸甲酯（MJA）处理提高多达60%。
