具有显著DNA结合亲和力的C8连接的吡咯并[2,1-c][1,4]苯并二氮杂卓-苯并咪唑缀合物的合成。
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
作者信息
Kamal Ahmed, Ramulu P, Srinivas O, Ramesh G, Kumar P Praveen
机构信息
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India.
出版信息
Bioorg Med Chem Lett. 2004 Sep 20;14(18):4791-4. doi: 10.1016/j.bmcl.2004.06.069.
PMID:15324909
Abstract
Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
摘要
已合成了两种类型的苯并咪唑，并通过不同的烷基链间隔基在C8位与DC-81相连。这些PBD缀合物表现出显著的DNA结合亲和力，一种代表性化合物显示出有前景的体外抗癌活性。
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