Kamal Ahmed, Kumar P Praveen, Sreekanth K, Seshadri B N, Ramulu P
Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2594-8. doi: 10.1016/j.bmcl.2008.03.039. Epub 2008 Mar 16.
The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.
本文描述了新型苯并咪唑连接的吡咯并苯并二氮杂卓缀合物的合成。其中一些缀合物表现出显著的DNA结合亲和力，代表性化合物4c对多种人类癌细胞系显示出有前景的体外细胞毒性。
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