Waksman Javier C, Phillips Scott D
University of Colorado Health Sciences Center Denver, CO, CO 80262, USA.
Clin Occup Environ Med. 2004 Aug;4(3):413-21, v. doi: 10.1016/j.coem.2004.03.001.
This article presents the current knowledge and clinical applications of the use of biomarkers of exposure to the halogenated solvents 1,1,1 trichloroethane (methylchloroform), trichloroethylene, tetrachloroethylene (perchloroethylene), and 1,1 dichloroethylene (vinylidene chloride). Although some studies have shown that protein and DNA adducts may form with chlorinated hydrocarbons, their application has not been validated sufficiently to justify their use as biologic markers of exposure.
本文介绍了卤代溶剂1,1,1-三氯乙烷（甲基氯仿）、三氯乙烯、四氯乙烯（全氯乙烯）和1,1-二氯乙烯（偏二氯乙烯）暴露生物标志物的当前知识及临床应用。尽管一些研究表明蛋白质和DNA加合物可能与氯代烃形成，但其应用尚未得到充分验证，不足以证明其可作为暴露的生物学标志物。
