Monster A C
J Occup Med. 1986 Aug;28(8):583-8. doi: 10.1097/00043764-198608000-00012.
The possibility of biological monitoring of exposure to some volatile, halogenated hydrocarbons will be discussed. Most of these agents are widely used as solvents. All agents act on the nervous system as narcotics and differ widely in toxicity. Most of the solvents undergo biotransformation to metabolites. This allows biological assessment of exposure by measurement of the solvent and/or metabolites in exhaled air, blood, and/or urine. However, the same metabolites may occur with exposure to different chlorinated hydrocarbons, eg, trichloroethanol and trichloroacetic acid from exposure to trichloroethene, tetrachloroethene, and 1,1,1-trichloroethane. On the other hand, these agents differ widely in the percentage that is metabolized. There are large gaps in our knowledge, however, and much research will have to be carried out before even tentative data can be established for most of the solvents.
将讨论对某些挥发性卤代烃暴露进行生物监测的可能性。这些物质大多被广泛用作溶剂。所有这些物质作为麻醉剂作用于神经系统，毒性差异很大。大多数溶剂会生物转化为代谢产物。这使得通过测量呼出气体、血液和/或尿液中的溶剂和/或代谢产物来对暴露进行生物评估成为可能。然而，接触不同的氯代烃可能会产生相同的代谢产物，例如，接触三氯乙烯、四氯乙烯和1,1,1-三氯乙烷会产生三氯乙醇和三氯乙酸。另一方面，这些物质的代谢百分比差异很大。然而，我们的知识存在很大空白，在为大多数溶剂建立初步数据之前，还需要进行大量研究。
