添加核苷酸的营养支持有利于重度营养不良婴儿的免疫反应。

Nutritional support with nucleotide addition favors immune response in severely malnourished infants.

作者信息

Vásquez-Garibay Edgar, Méndez-Estrada Concepción, Romero-Velarde Enrique, García-Iglesias Ma Trinidad, Campollo-Rivas Octavio

机构信息

Instituto de Nutrición Humana, Departamento de Reproducción Humana, Crecimiento y Desarrollo Infantil, 44340 Guadalajara, Jalisco, Mexico.

出版信息

Arch Med Res. 2004 Jul-Aug;35(4):284-8. doi: 10.1016/j.arcmed.2004.03.002.

DOI:10.1016/j.arcmed.2004.03.002

PMID:15325501

Abstract

BACKGROUND

Adequate nutritional support of severe primary protein energy malnutrition (PEM) is indispensable for achieving normal immune response. However, an ideal dietetic criterion has not yet been established or accepted by the majority of health professionals caring for malnourished infants. Our objective was to demonstrate improvement in immune response in infants with PEM who received starting infant formula with nucleotides.

METHODS

Twelve malnourished infants 3-18 months of age were included in our study and were fed through a nasogastric tube with infant formula (3.35 kJ/mL) for 2 weeks and ad libitum for an additional 2 weeks. Anthropometric measurements and immunologic indicators such as phagocytosis, microbicidal activity, chemotaxis, and cell proliferation index were determined. The sample was divided into two groups; group 1 (n=6) was fed formula with nucleotides added, while group 2 (n=6) was fed a formula with no nucleotides. Paired t test was used to determine differences between initial and final results for each group for comparison between group 1 vs. group 2; a nonparametric Mann-Whitney U test was used for immunologic indicators.

RESULTS

Comparison of immunologic indicators showed no significant difference between groups. Groups 1 and 2 showed improvement in phagocytosis and microbicidal activity (p <0.05) and group 2 additionally showed improvement in cell proliferation index.

CONCLUSIONS

Infant formula with intake of 837 kJ/kg/d (200 kcal/kg/d) and proteins of 4 g/kg/d in infants with PEM had a favorable impact on immunologic indicators regardless of addition of nucleotides.

摘要

背景

对于严重的原发性蛋白质能量营养不良（PEM），充足的营养支持对于实现正常免疫反应必不可少。然而，目前尚未建立理想的饮食标准，也未被大多数照料营养不良婴儿的健康专业人员所接受。我们的目的是证明接受含核苷酸起始婴儿配方奶粉的PEM婴儿的免疫反应有所改善。

方法

12名3至18个月大的营养不良婴儿纳入我们的研究，通过鼻胃管喂食婴儿配方奶粉（3.35 kJ/mL）2周，之后随意喂食2周。测定人体测量指标和免疫指标，如吞噬作用、杀菌活性、趋化性和细胞增殖指数。样本分为两组；第1组（n = 6）喂食添加核苷酸的配方奶粉，而第2组（n = 6）喂食不含核苷酸的配方奶粉。采用配对t检验确定每组初始和最终结果之间的差异，以比较第1组和第2组；免疫指标采用非参数曼-惠特尼U检验。