Virga Jesseziekenhuis, Pediatrics, Hasselt, Belgium.
Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e377-85. doi: 10.1111/j.1399-3038.2009.00957.x. Epub 2009 Dec 9.
This double-blind, randomized, placebo-controlled study, aimed to explore the effect of an infant milk formula (IMF) with 6 g/l short-chain galacto- and long-chain fructo-oligosaccharides (scGOS/lcFOS, ratio 9:1) on basal immune parameters in 215 healthy, term infants during the first 26 wk of life. After birth, the infants received breast milk or were randomized to receive an IMF with or without scGOS/lcFOS. Blood samples were collected at the age of 8 wk and 26 wk for the analysis of serum immunoglobulins, lymphocyte subpopulations, and cytokines. The scGOS/lcFOS group and the control group were compared in the statistical analysis. A breast fed group was included as a reference. In total, 187 Infants completed the study. No significant differences were observed between both formula groups in the different studied immune parameters at weeks 8 and 26. This explorative study indicates that supplementation of infant formula with a mixture of prebiotic oligosaccharides did not change the basal level of the measured parameters of the developing immune system in healthy infants with a balanced immune system during the first 6 months of life in comparison to feeding a standard infant formula and in comparison to exclusive breastfeeding.
本双盲、随机、安慰剂对照研究旨在探讨含有 6g/L 短链半乳糖和长链果糖低聚糖（scGOS/lcFOS，比例 9:1）的婴儿配方奶粉（IMF）对 215 名健康足月婴儿基础免疫参数的影响，研究时间为生命的头 26 周。出生后，婴儿接受母乳喂养或随机接受添加或不添加 scGOS/lcFOS 的 IMF。在 8 周和 26 周时采集血样，用于分析血清免疫球蛋白、淋巴细胞亚群和细胞因子。在统计分析中比较了 scGOS/lcFOS 组和对照组。同时还纳入了母乳喂养组作为参考。共有 187 名婴儿完成了这项研究。在第 8 周和第 26 周时，两组配方奶在不同研究的免疫参数方面均无显著差异。这项探索性研究表明，与喂养标准婴儿配方奶粉和母乳喂养相比，在生命的头 6 个月，健康婴儿的免疫系统处于平衡状态，添加含有益生元低聚糖的婴儿配方奶粉不会改变正在发育的免疫系统的基础水平。
