激素状态和口服摄入量对HIV感染男性相位角的影响。

Influence of hormonal status and oral intake on phase angle in HIV-infected men.

作者信息

de Luis Daniel A, Aller Rocio, Bachiller Pablo, Gonzalez Sagrado M, Martin Javier, Izaola Olatz

机构信息

Institute of Endocrinology and Nutrition, Section on Endocrinology and Nutrition, Unidad de Apoyo a la Investigación, H Universitario Río Hortega, Valladolid, Spain.

出版信息

Nutrition. 2004 Sep;20(9):731-4. doi: 10.1016/j.nut.2004.05.017.

DOI:10.1016/j.nut.2004.05.017

PMID:15325677

Abstract

OBJECTIVE

Phase angle alpha can be easily obtained from bioelectrical impedance analysis. In the literature, this angle is the single best predictor of survival in patients with the human immunodeficiency virus (HIV). The aim of our study was to detect nutritional and biochemical parameters that influence the phase angle.

METHODS

One hundred men with HIV were studied. In all patients, anthropometric and biochemical nutritional evaluations were performed. Basal concentrations of testosterone and somatomedin C (insulin-like growth factor-1) were measured. Tetrapolar bioelectrical impedance analysis was used to determine body composition. All patients received instruction on keeping 24-h written food records. Albumin, prealbumin, transferrin, CD4 count, and total lymphocytes were measured.

RESULTS

Patients' mean age was 39.1 +/- 9.9 y, mean body weight was 66.8 +/- 11.2 kg, and mean body mass index was 22.5 +/- 3.5 kg/m2. Patients' average fat-free mass was 58.05 +/- 8.7 kg and average fat mass was 9.17 +/- 4.9 kg. Average phase angle alpha was 8.21 +/- 0.88 degrees. Patients were assigned to one of two groups according to phase angle: those with a phase angle alpha smaller than 8.2 degrees (group 1) and those with a phase angle alpha of at least 8.2 degrees (group 2). Weight, body mass index, transferrin, and somatomedin C were significantly higher in group 2 (P < 0.05 for all). There were significant positive correlations between phase angle alpha and somatomedin C (r = 0.3, P < 0.05) and protein intake (r = 0.2, P < 0.05). In the multivariate analysis (adjusted for number of antiretroviral drugs prescribed, age, disease stage, and energy and protein intakes), only somatomedin C remained in the model (F = 4.5, P < 0.05), with an increase in phase angle alpha of 0.56 degrees (95% confidence interval, 0.04 to 1.08) with each 1-nM/L increase in somatomedin C.

CONCLUSION

Somatomedin C and protein intake influenced phase angle alpha, but only somatomedin C remained as an independent factor in the multivariate analysis.

摘要

目的

通过生物电阻抗分析可轻松获得相角α。在文献中，该角度是人类免疫缺陷病毒（HIV）患者生存的最佳单一预测指标。我们研究的目的是检测影响相角的营养和生化参数。

方法

对100名HIV男性患者进行研究。对所有患者进行人体测量和生化营养评估。测量睾酮和生长调节素C（胰岛素样生长因子-1）的基础浓度。采用四极生物电阻抗分析来确定身体成分。所有患者均接受记录24小时饮食的指导。测量白蛋白、前白蛋白、转铁蛋白、CD4细胞计数和总淋巴细胞数。

结果

患者的平均年龄为39.1±9.9岁，平均体重为66.8±11.2 kg，平均体重指数为22.5±3.5 kg/m²。患者的平均去脂体重为58.05±8.7 kg，平均脂肪量为9.17±4.9 kg。平均相角α为8.21±0.88度。根据相角将患者分为两组：相角α小于8.2度的患者（第1组）和相角α至少为8.2度的患者（第2组）。第2组的体重、体重指数、转铁蛋白和生长调节素C显著更高（所有P<0.05）。相角α与生长调节素C（r = 0.3，P<0.05）和蛋白质摄入量（r = 0.2，P<0.05）之间存在显著正相关。在多变量分析中（根据抗逆转录病毒药物处方数量、年龄、疾病阶段以及能量和蛋白质摄入量进行调整），模型中仅保留了生长调节素C（F = 4.5，P<0.05），生长调节素C每增加1 nM/L，相角α增加0.56度（95%置信区间，0.04至1.08）。