Gammon Marilie D, Eng Sybil M, Teitelbaum Susan L, Britton Julie A, Kabat Geoffrey C, Hatch Maureen, Paykin Andrea B, Neugut Alfred I, Santella Regina M
Department of Epidemiology, School of Public Health, University of North Carolina, CB#7435 McGavern-Greenberg Hall, Chapel Hill, NC 27599-7435, USA.
Environ Res. 2004 Oct;96(2):176-85. doi: 10.1016/j.envres.2003.08.009.
To evaluate whether environmental tobacco smoke (ETS) influences breast cancer incidence, data from a population-based case-control study were analyzed. Respondents with available ETS information assessed by in-person questionnaires included 1356 newly diagnosed cases and 1383 controls. Relative to nonsmokers who reported no residential ETS exposure throughout the life course, the odds ratios (OR) for breast cancer were not substantially elevated in relation to ETS exposure, active smoking, or a joint measure of active and passive smoking (OR, 1.15, 95% CI, 0.90, 1.48). An increased OR, however, was noted among nonsmokers who lived with a smoking spouse for over 27 years (2.10, 95% CI, 1.47, 3.02), although no dose-response was evident. Also, among women with hormone-receptor-positive tumors only, the OR for both active and passive smoking was increased (1.42 for ER+ PR+, 95% CI, 1.00, 2.00). Our data suggest that if there is an effect for ETS on breast cancer, that effect is restricted to selected subgroups of women, such as those with long-term exposure from a smoking spouse.
为评估环境烟草烟雾（ETS）是否会影响乳腺癌发病率，我们分析了一项基于人群的病例对照研究的数据。通过面对面问卷调查获得ETS信息的受访者包括1356例新诊断病例和1383名对照。与报告在整个生命过程中无家庭ETS暴露的非吸烟者相比，ETS暴露、主动吸烟或主动与被动吸烟联合测量情况下的乳腺癌比值比（OR）并未显著升高（OR，1.15，95%CI，0.90，1.48）。然而，与吸烟配偶共同生活超过27年的非吸烟者中观察到OR升高（2.10，95%CI，1.47，3.02），尽管未发现剂量反应关系。此外，仅在激素受体阳性肿瘤的女性中，主动和被动吸烟的OR均升高（ER+PR+为1.42，95%CI，1.00，2.00）。我们的数据表明，如果ETS对乳腺癌有影响，那么这种影响仅限于特定的女性亚组，例如那些长期暴露于吸烟配偶的女性。
