Burri Betty J, Clifford Andrew J
Western Human Nutrition Research Center, ARS/USDA, Davis, CA 95616, USA.
Arch Biochem Biophys. 2004 Oct 1;430(1):110-9. doi: 10.1016/j.abb.2004.04.028.
Use of isotopes as tracers has had an important role in elucidating key features of vitamin A and retinoid metabolism in animal models and humans. Their use has shown that beta-carotene absorption is variable, and that the appearance of beta-carotene and its metabolites in the blood by time since dosing follows characteristic patterns. Retinol formed from beta-carotene shows a different pattern, as does lutein. In this article, we summarize and discuss insights and some surprises into the absorption and metabolism of vitamin A, beta-carotene, and lutein that were gained with the use of isotope tracers in humans, rats, and cells as models.
使用同位素作为示踪剂在阐明动物模型和人类中维生素A和类视黄醇代谢的关键特征方面发挥了重要作用。它们的使用表明，β-胡萝卜素的吸收是可变的，并且自给药后β-胡萝卜素及其代谢产物在血液中的出现随时间遵循特征模式。由β-胡萝卜素形成的视黄醇表现出不同的模式，叶黄素也是如此。在本文中，我们总结并讨论了以人类、大鼠和细胞为模型使用同位素示踪剂所获得的关于维生素A、β-胡萝卜素和叶黄素吸收与代谢的见解及一些意外发现。
