van Vliet T
TNO Nutrition and Food Research Institute, Zeist, Netherlands.
Eur J Clin Nutr. 1996 Jul;50 Suppl 3:S32-7.
To review available information on absorption and further metabolism of different carotenoids in man and to discuss animal models and approaches in the study of carotenoid absorption and metabolism in man.
Humans appear to absorb various carotenoids in a relatively non-specific fashion, but absorption kinetics and plasma transport seem to differ among carotenoids, possibly because of differences in polarity. Absorbed beta-carotene for the most part is converted, mainly into retinyl esters, but several details with respect to the cleavage reaction remain to be elucidated. Although interactions among carotenoids do exist, their importance and the mechanisms involved are still unclear. No animal model reflects the human situation for beta-carotene metabolism entirely. Thus, for every research question, the optimal model needs to be selected. Methods available for studying beta-carotene metabolism in man are limited. The most promising methods are the single dose-response in chylomicrons, and plasma responses after dosing with stable isotopes.
回顾关于不同类胡萝卜素在人体中的吸收及进一步代谢的现有信息，并讨论人体类胡萝卜素吸收和代谢研究中的动物模型及方法。
人类似乎以相对非特异性的方式吸收各种类胡萝卜素，但类胡萝卜素之间的吸收动力学和血浆转运似乎存在差异，这可能是由于极性不同所致。吸收的β-胡萝卜素大部分被转化，主要转化为视黄酯，但关于裂解反应的几个细节仍有待阐明。虽然类胡萝卜素之间确实存在相互作用，但其重要性和相关机制仍不清楚。没有动物模型能完全反映人体β-胡萝卜素代谢的情况。因此，对于每个研究问题，都需要选择最佳模型。用于研究人体β-胡萝卜素代谢的现有方法有限。最有前景的方法是乳糜微粒中的单剂量反应以及给予稳定同位素后的血浆反应。
