Svatikova Anna, Shamsuzzaman Abu S, Wolk Robert, Phillips Bradley G, Olson Lyle J, Somers Virend K
Mayo Clinic Foundation, 200 First Street SW, Rochester, MH 55905, USA.
Am J Cardiol. 2004 Aug 15;94(4):529-32. doi: 10.1016/j.amjcard.2004.05.010.
We compared brain natriuretic peptide (BNP) levels in patients with obstructive sleep apnea (OSA) with and without cardiovascular disease to BNP in healthy control subjects. OSA was not associated with increased plasma BNP or atrial natriuretic peptide (ANP) in otherwise healthy subjects during wakefulness. Untreated OSA increased ANP overnight, and ANP levels decreased with treatment of OSA. However, OSA did not elicit acute overnight changes in BNP, either in normal subjects or in patients with coexisting cardiovascular disease (including chronic heart failure).
我们将患有和未患有心血管疾病的阻塞性睡眠呼吸暂停（OSA）患者的脑钠肽（BNP）水平与健康对照者的BNP水平进行了比较。在清醒状态下，对于其他方面健康的受试者，OSA与血浆BNP或心房钠尿肽（ANP）升高无关。未经治疗的OSA会使ANP在夜间升高，而ANP水平会随着OSA的治疗而降低。然而，无论是在正常受试者还是在合并心血管疾病（包括慢性心力衰竭）的患者中，OSA均未引起BNP的急性夜间变化。
