短暂性全面性遗忘症和短暂性脑缺血发作中的活化血小板

Activated platelets in transient global amnesia and TIA.

作者信息

Hirabayashi Hisayuki, Shimizu Mie, Kohara Saori, Shinohara Yukito

机构信息

Department of Neurology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259-1193, Japan.

出版信息

Neurology. 2004 Aug 24;63(4):736-8. doi: 10.1212/01.wnl.0000134602.92612.be.

DOI:10.1212/01.wnl.0000134602.92612.be

PMID:15326257

Abstract

To assess whether platelets are activated in transient global amnesia (TGA) and TIA, blood samples were analyzed by fluorescence-activated cytoscan using antibodies specific for platelet fibrinogen receptor (PAC1) and P-selectin (CD62P). Samples from TIA contained high levels of CD62P compared with age-matched control subjects, whereas those from TGA did not. The authors suggest that activated platelets are involved in brain ischemia, whereas ischemia appears not to be associated with most TGA.

摘要

为评估短暂性全面性遗忘症（TGA）和短暂性脑缺血发作（TIA）中血小板是否被激活，使用针对血小板纤维蛋白原受体（PAC1）和P-选择素（CD62P）的特异性抗体，通过荧光激活细胞扫描分析血样。与年龄匹配的对照受试者相比，TIA患者的血样中CD62P水平较高，而TGA患者的血样中则没有。作者认为，活化的血小板与脑缺血有关，而缺血似乎与大多数TGA无关。