一项关于短暂性全面性遗忘症的病例对照研究。
A case-control study of transient global amnesia.
作者信息
Guidotti M, Anzalone N, Morabito A, Landi G
机构信息
Neurological Clinic, University of Milan, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):320-3. doi: 10.1136/jnnp.52.3.320.
To evaluate risk factors and prognosis of transient global amnesia (TGA), three groups of 30 subjects each affected respectively by: (1) first-ever TGA; (2) first-ever transient ischaemic attack (TIA); (3) depressive neurosis, were compared. Prevalence of cerebrovascular risk factors was similar in patients with TGA and TIA, but significantly lower in the third group. CT showed more hypodense lesions in TIA patients than in those with TGA. In a mean follow-up of 36 months, five TGA patients experienced a TIA and three others had recurrence of TGA, but none suffered stroke or myocardial infarction. In the TIA group, four had recurrence of TIA, two suffered a stroke and two others a myocardial infarction, whereas none had TGA attacks. None of the patients of the third group had any ischaemic event during follow-up. The similar prevalence of risk factors, but the different prognosis between TGA and TIA patients, suggest that TGA is an ischaemic event, probably not triggered by thromboembolism but by a different, possibly vasospastic, mechanism.
为评估短暂性全面性遗忘症（TGA）的危险因素及预后，对三组各30名受试者进行了比较，这三组受试者分别患有：（1）首次发作的TGA；（2）首次发作的短暂性脑缺血发作（TIA）；（3）抑郁性神经症。TGA和TIA患者中脑血管危险因素的患病率相似，但第三组显著更低。CT显示TIA患者的低密度病变比TGA患者更多。在平均36个月的随访中，5名TGA患者发生了TIA，另外3名出现了TGA复发，但无一例发生中风或心肌梗死。在TIA组中，4例出现TIA复发，2例发生中风，另外2例发生心肌梗死，而无一例有TGA发作。第三组患者在随访期间均未发生任何缺血性事件。危险因素患病率相似，但TGA和TIA患者的预后不同，这表明TGA是一种缺血性事件，可能不是由血栓栓塞触发，而是由不同的、可能是血管痉挛的机制触发。
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