Roper Cally, Pearce Richard, Nair Shalini, Sharp Brian, Nosten François, Anderson Tim
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Science. 2004 Aug 20;305(5687):1124. doi: 10.1126/science.1098876.
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
在此，我们提供分子证据表明，携带高水平乙胺嘧啶抗性的疟原虫最初是从东南亚抵达非洲的。这些迁徙疟原虫携带的抗性等位基因目前正在以惊人的速度在非洲传播，这预示着负担得起的疟疾治疗即将终结，并给撒哈拉以南非洲带来一场公共卫生危机。
