Brokken L J S, Leendertse M, Bakker O, Wiersinga W M, Prummel M F
Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105-AZ Amsterdam, The Netherlands.
Horm Metab Res. 2004 Aug;36(8):538-41. doi: 10.1055/s-2004-825758.
Adenohypophyseal-hormone production is regulated by hypothalamic peptides and target-gland hormones. Additionally, paracrine regulation by folliculo-stellate cells within the pituitary has been suggested. We recently showed TSH receptor expression in human folliculo-stellate cells and speculated that receptors for other adenohypophyseal hormones might also be expressed by folliculo-stellate cells. Using RT-PCR, we evaluated the expression of receptors for TSH, GH, ACTH, LH, FSH and PRL in a murine folliculo-stellate cell line, TtT/GF. Transcripts of TSH receptor, GH receptor and ACTH receptor were detected in this cell line. LH receptor, FSH receptor and PRL receptor expression, however, could not be demonstrated. We conclude that the TtT/GF cells express some, but not all, receptors for anterior pituitary hormones. This indicates that folliculo-stellate cells might act as mediators in the paracrine regulation of at least some of the hormones secreted by the anterior pituitary.
腺垂体激素的产生受下丘脑肽类和靶腺激素调节。此外，有人提出垂体中滤泡星状细胞存在旁分泌调节。我们最近发现人滤泡星状细胞中存在促甲状腺激素（TSH）受体表达，并推测滤泡星状细胞可能也表达其他腺垂体激素的受体。我们利用逆转录聚合酶链反应（RT-PCR）评估了小鼠滤泡星状细胞系TtT/GF中TSH、生长激素（GH）、促肾上腺皮质激素（ACTH）、促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素（PRL）受体的表达。在该细胞系中检测到了TSH受体、GH受体和ACTH受体的转录本。然而，未证实有LH受体、FSH受体和PRL受体表达。我们得出结论，TtT/GF细胞表达部分而非全部垂体前叶激素受体。这表明滤泡星状细胞可能至少在某些垂体前叶分泌激素的旁分泌调节中充当介质。
