Testa Julie A, Ivnik Robert J, Boeve Bradley, Petersen Ronald C, Pankratz V Shane, Knopman David, Tangalos Eric, Smith Glenn E
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55901, USA.
J Int Neuropsychol Soc. 2004 Jul;10(4):504-12. doi: 10.1017/S1355617704104177.
As the incidence of dementia increases, there is a growing need to determine the diagnostic utility of specific neuropsychological tests in the early diagnosis of Alzheimer's disease (AD). In this study, the relative utility of Boston Naming Test (BNT) in the diagnosis of AD was examined and compared to the diagnostic utility of other neuropsychological measures commonly used in the evaluation of AD. Individuals with AD (n = 306), Mild Cognitive Impairment (MCI; n = 67), and cognitively normal subjects (n = 409) with at least 2 annual evaluations were included. Logistic regression analysis suggested that initial BNT impairment is associated with increased risk of subsequent AD diagnosis. However, this risk is significantly less than that imparted by measures of delayed recall impairments. A multivariate Cox proportional hazards regression analysis suggested that BNT impairment imparted no additional risk for subsequent AD diagnosis after delayed recall impairments were included in the model. Although BNT impairment occurred in all severity groups, it was ubiquitous only in moderate to severe dementia. Collectively these results suggest that although BNT impairments become more common as AD progresses, they are neither necessary for the diagnosis of AD nor particularly useful in identifying early AD.
随着痴呆症发病率的上升，确定特定神经心理学测试在阿尔茨海默病（AD）早期诊断中的诊断效用的需求日益增长。在本研究中，研究了波士顿命名测试（BNT）在AD诊断中的相对效用，并将其与AD评估中常用的其他神经心理学测量方法的诊断效用进行了比较。纳入了患有AD（n = 306）、轻度认知障碍（MCI；n = 67）以及认知正常（n = 409）且至少接受过2次年度评估的个体。逻辑回归分析表明，初始BNT损伤与后续AD诊断风险增加相关。然而，这种风险显著低于由延迟回忆损伤测量所带来的风险。多变量Cox比例风险回归分析表明，在模型中纳入延迟回忆损伤后，BNT损伤并未为后续AD诊断带来额外风险。尽管BNT损伤在所有严重程度组中均有发生，但仅在中度至重度痴呆中普遍存在。总体而言，这些结果表明，尽管随着AD进展BNT损伤变得更为常见，但它们对于AD诊断既非必要条件，在识别早期AD方面也并非特别有用。
