Chambliss Heather O, Van Hoomissen Jacqueline D, Holmes Philip V, Bunnell Bradford N, Dishman Rod K
Centers for Integrated Health Research, The Cooper Institute, Dallas, TX, USA.
Physiol Behav. 2004 Sep 30;82(4):593-600. doi: 10.1016/j.physbeh.2004.04.064.
We examined the effects of chronic activity wheel running and imipramine administration on appetitive behavior after olfactory bulbectomy (OBX). Male Long-Evans rats were randomly assigned to the following conditions using a 2 x 2 x 2 design: (1) bilateral OBX or sham surgery, (2) voluntary activity wheel running or sedentary home cage, and (3) daily imipramine or saline injections. After 21 days of treatment, animals underwent behavioral testing for copulatory activity and sucrose preference. Bulbectomized animals exhibited decrements in copulatory performance and reductions in sucrose intake compared to sham animals. Within the bulbectomized groups, imipramine-treated rats either did not copulate or had reduced ejaculation frequencies. However, activity wheel running attenuated the copulatory deficits induced by OBX. The findings encourage studies of physical activity and male sexual dysfunction among depressed men being treated by pharmacotherapy.
我们研究了长期进行活动轮跑步和给予丙咪嗪对嗅球切除术后（OBX）的食欲行为的影响。使用2×2×2设计将雄性Long-Evans大鼠随机分配到以下条件：（1）双侧OBX或假手术，（2）自愿进行活动轮跑步或久坐于饲养笼，以及（3）每日注射丙咪嗪或生理盐水。治疗21天后，对动物进行交配活动和蔗糖偏好的行为测试。与假手术动物相比，嗅球切除的动物交配性能下降，蔗糖摄入量减少。在嗅球切除组中，接受丙咪嗪治疗的大鼠要么不交配，要么射精频率降低。然而，活动轮跑步减轻了OBX诱导的交配缺陷。这些发现鼓励对接受药物治疗的抑郁症男性中的身体活动和男性性功能障碍进行研究。
