长期护理机构中对喹诺酮耐药的流感嗜血杆菌：编码DNA促旋酶和DNA拓扑异构酶IV的基因改变的核苷酸序列特征
Quinolone-resistant Haemophilus influenzae in a long-term-care facility: nucleotide sequence characterization of alterations in the genes encoding DNA gyrase and DNA topoisomerase IV.
作者信息
Li Xinying, Mariano Noriel, Rahal James J, Urban Carl M, Drlica Karl
机构信息
Public Health Research Institute, 225 Warren St., Newark, NJ 07103, USA.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3570-2. doi: 10.1128/AAC.48.9.3570-3572.2004.
Abstract
Fluoroquinolone-resistant isolates of Haemophilus influenzae, obtained from a long-term care facility, were examined for nucleotide sequence differences in the quinolone-resistance-determining regions of gyrA, gyrB, parC, and parE. Similarities among the resistant isolates, plus multiple differences with susceptible isolates, suggest clonal dissemination involving two resistant subclones.
摘要
从一家长期护理机构获得的耐氟喹诺酮流感嗜血杆菌分离株，对其gyrA、gyrB、parC和parE喹诺酮耐药决定区的核苷酸序列差异进行了检测。耐药分离株之间的相似性，加上与敏感分离株的多处差异，提示存在涉及两个耐药亚克隆的克隆传播。
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