韩国临床呼吸道分离的流感嗜血杆菌左氧氟沙星敏感性降低与 DNA 回旋酶和拓扑异构酶 II 基因突变无关。
Reduced levofloxacin susceptibility in clinical respiratory isolates of Haemophilus influenzae is not yet associated with mutations in the DNA gyrase and topoisomerase II genes in Korea.
机构信息
Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.
出版信息
Yonsei Med J. 2011 Jan;52(1):188-91. doi: 10.3349/ymj.2011.52.1.188.
Abstract
Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs ≥ 0.5 μg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon suggests that neither evolution nor spread of any significant QRDRs mutations in clinical isolates occurred in Korea. Therefore, continued surveillance is necessary to observe the evolution of antibiotic-resistance and take measures to avoid the spread of drug-resistant clones.
摘要
在韩国的 155 株临床呼吸道分离流感嗜血杆菌中，有 6 株（3.9%）对左氧氟沙星的敏感性降低（MIC≥0.5μg/ml）。这 6 株分离株在 gyrA、gyrB、parC 或 parE 中没有明显的喹诺酮耐药决定区（QRDR）突变。这种现象表明，韩国临床分离株中任何重要的 QRDRs 突变都没有发生进化或传播。因此，需要继续进行监测，以观察抗生素耐药性的演变，并采取措施避免耐药克隆的传播。
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