Decousser Jean-Winoc, Pina Patrick, Viguier Florent, Picot Franc, Courvalin Patrice, Allouch Pierre
Centre Hospitalier de Versailles André Mignot, Service d'Hygiène Hospitalière, 177 rue de Versailles, 78157 Le Chesnay Cedex, France.
Antimicrob Agents Chemother. 2004 Sep;48(9):3636-9. doi: 10.1128/AAC.48.9.3636-3639.2004.
A study of 257 French invasive pneumococci isolated between 2000 and 2002 showed high rates of nonsusceptibility to penicillin and macrolides (50%), contrasting with a low frequency of resistance to amoxicillin or levofloxacin (<1%) and tolerance to vancomycin (0%). The genetic homogeneity of some serogroups, including serogroup 1, enhanced the risk of epidemiological changes.
一项针对2000年至2002年间分离出的257株法国侵袭性肺炎球菌的研究表明,这些菌株对青霉素和大环内酯类药物的不敏感率很高(50%),与之形成对比的是,对阿莫西林或左氧氟沙星的耐药率较低(<1%),对万古霉素的耐受性为零(0%)。包括1血清型在内的一些血清型的基因同质性增加了流行病学变化的风险。