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采用锁核酸探针的新型实时聚合酶链反应检测法评估法国氟喹诺酮敏感肺炎链球菌分离株中ParC突变的流行情况。

New real-time PCR assay using locked nucleic acid probes to assess prevalence of ParC mutations in fluoroquinolone-susceptible Streptococcus pneumoniae isolates from France.

作者信息

Decousser Jean-Winoc, Methlouthi Imen, Pina Patrick, Collignon Anne, Allouch Pierre

机构信息

Laboratoire de Biologie, Centre Hospitalier de Dourdan, 2 Rue du Potelet, 91415 Dourdan, France.

出版信息

Antimicrob Agents Chemother. 2006 Apr;50(4):1594-8. doi: 10.1128/AAC.50.4.1594-1598.2006.

DOI:10.1128/AAC.50.4.1594-1598.2006
PMID:16569894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1426917/
Abstract

A real-time PCR assay with locked nucleic acid probes was developed to screen mutations at codons 79 and 83 of the Streptococcus pneumoniae parC gene. Only silent mutations were detected among 236 French invasive fluoroquinolone-susceptible strains. This test could be useful for some high-risk patients or in national surveys.

摘要

开发了一种使用锁核酸探针的实时聚合酶链反应检测方法，以筛查肺炎链球菌parC基因第79和83密码子处的突变。在236株法国侵袭性氟喹诺酮敏感菌株中仅检测到沉默突变。该检测方法可能对一些高危患者或全国性调查有用。

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本文引用的文献

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A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance.与氟喹诺酮耐药相关的肺炎链球菌感染治疗失败的综述。
Clin Infect Dis. 2005 Jul 1;41(1):118-21. doi: 10.1086/430829. Epub 2005 May 26.
2
Fluoroquinolone prescribing in the United States: 1995 to 2002.美国1995年至2002年氟喹诺酮类药物的处方情况
Am J Med. 2005 Mar;118(3):259-68. doi: 10.1016/j.amjmed.2004.09.015.
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Outpatient antibiotic use in Europe and association with resistance: a cross-national database study.欧洲门诊抗生素使用情况及其与耐药性的关联：一项跨国数据库研究。
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The molecular epidemiology of Streptococcus pneumoniae with quinolone resistance mutations.具有喹诺酮耐药性突变的肺炎链球菌的分子流行病学
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Relationship between increased levofloxacin use and decreased susceptibility of Streptococcus pneumoniae in the United States.美国左氧氟沙星使用增加与肺炎链球菌易感性降低之间的关系。
Diagn Microbiol Infect Dis. 2005 Jan;51(1):31-7. doi: 10.1016/j.diagmicrobio.2004.08.017.
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Fluoroquinolone resistance in penicillin-resistant Streptococcus pneumoniae clones, Spain.西班牙青霉素耐药肺炎链球菌克隆株中的氟喹诺酮耐药性
Emerg Infect Dis. 2004 Oct;10(10):1751-9. doi: 10.3201/eid1010.040382.
7
Invasive Streptococcus pneumoniae in France: antimicrobial resistance, serotype, and molecular epidemiology findings from a monthly national study in 2000 to 2002.法国侵袭性肺炎链球菌：2000年至2002年每月全国性研究的抗菌药物耐药性、血清型及分子流行病学研究结果
Antimicrob Agents Chemother. 2004 Sep;48(9):3636-9. doi: 10.1128/AAC.48.9.3636-3639.2004.
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Designing fluoroquinolone breakpoints for Streptococcus pneumoniae by using genetics instead of pharmacokinetics-pharmacodynamics.通过遗传学而非药代动力学-药效学设计肺炎链球菌的氟喹诺酮类药物断点。
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