Ohta Makoto, Handa Akira, Iwata Hiroo, Rüfenacht Daniel A, Tsutsumi Sadami
Section of Neuroradiology, Department of Radiology, Geneva University Hospital, Switzerland.
Technol Health Care. 2004;12(3):225-33.
To develop a vessel model with poly-vinyl alcohol hydrogel (PVA-H) with low surface friction for in vitro simulations of vascular pathologies.
Simulations of variable vascular pathologies were based on human vessel casts reproduced in wax. Constructions of vascular models were then obtained by lost wax techniques. As materials, liquid silicon or PVA in organic solvents were used. After solidification, the wax was drained by heating. Comparison of PVA-H with silicone models included evaluation of surface characteristics (friction coefficient), of visibility (transparence and compatibility with medical imaging techniques), and of stiffness (pulsatility of vascular lumen). Both model types were integrated in a circulation circuit allowing for flow simulations and testing with endovascular medical devices.
Both model types were transparent and compatible with current medical imaging methods. PVA-H models exhibited much lower friction characteristics. PVA-H stiffness was closer to soft tissue when compared to silicone, allowing for pulsations during flow simulations.
开发一种具有低表面摩擦力的聚乙烯醇水凝胶（PVA - H）血管模型，用于体外模拟血管病变。
基于蜡质复制的人体血管铸型对多种血管病变进行模拟。然后通过失蜡技术获得血管模型。使用的材料为液态硅或有机溶剂中的PVA。固化后，通过加热排出蜡。将PVA - H模型与硅酮模型进行比较，包括评估表面特性（摩擦系数）、可见性（透明度和与医学成像技术的兼容性）以及硬度（血管腔的搏动性）。两种模型类型都集成到一个循环回路中，以进行血流模拟并使用血管内医疗设备进行测试。
两种模型类型均为透明的，且与当前医学成像方法兼容。PVA - H模型表现出低得多的摩擦特性。与硅酮相比，PVA - H的硬度更接近软组织，在血流模拟过程中允许搏动。
