Lee Daniel K C, Haggart Kay, Lipworth Brian J
Asthma & Allergy Research Group, Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland.
Ann Allergy Asthma Immunol. 2004 Aug;93(2):185-8. doi: 10.1016/S1081-1206(10)61473-1.
Peak nasal inspiratory flow (PNIF) and acoustic rhinometry objectively measure the effects of nasal provocation testing. Although the latter is conventionally used in nasal lysine-aspirin challenge, use of the former in aspirin-induced asthma (AIA) has never been evaluated.
To evaluate the reproducibility of PNIF and acoustic rhinometry following nasal lysine-aspirin challenge in AIA.
Fourteen patients with a clear-cut history of AIA underwent nasal lysine-aspirin challenge at 2 separate visits 1 week apart. Both PNIF and minimum cross-sectional area (MCA) were measured using acoustic rhinometry for 120 minutes following standard nasal lysine-aspirin challenge (25 mg).
Prechallenge values were not significantly different at visit 1 vs visit 2 for mean [SEM] PNIF (128 [13] vs 127 [9] L/min) and MCA (6.89 [0.51] vs 6.94 [0.57] cm2). The mean (SEM) maximum percent PNIF change from baseline for visit 1 and visit 2 was -42 (5) and -42 (6), respectively, and the mean (SEM) average percent PNIF change from baseline was -25 (4) and -25 (6), respectively. The mean (SEM) maximum percent MCA change from baseline for visit 1 and visit 2 was -49 (4) and -48 (3), respectively, and the mean (SEM) average percent MCA change from baseline was -25 (8) and -24 (4), respectively. Coefficients of variation for maximum and average responses were 2.3% and 6.5%, respectively, for PNIF and 7.4% and 16.1% for MCA.
Measurement of PNIF following nasal lysine-aspirin challenge is a simple and reproducible alternative to acoustic rhinometry, with maximum response being a more reproducible outcome measure than average response.
鼻腔最大吸气流量（PNIF）和声反射鼻测量法可客观地测量鼻激发试验的效果。尽管声反射鼻测量法传统上用于赖氨酸阿司匹林鼻激发试验，但前者在阿司匹林诱发哮喘（AIA）中的应用从未得到评估。
评估赖氨酸阿司匹林鼻激发试验后AIA患者PNIF和声反射鼻测量法的可重复性。
14例有明确AIA病史的患者在相隔1周的2次独立就诊时接受赖氨酸阿司匹林鼻激发试验。在标准赖氨酸阿司匹林激发试验（25mg）后120分钟，使用声反射鼻测量法测量PNIF和最小横截面积（MCA）。
第1次就诊和第2次就诊时，激发前平均[标准误]PNIF（128[13] vs 127[9]L/min）和MCA（6.89[0.51] vs 6.94[0.57]cm²）的数值无显著差异。第1次就诊和第2次就诊时，PNIF自基线变化的平均（标准误）最大百分比分别为-42（5）和-42（6），PNIF自基线变化的平均（标准误）平均百分比分别为-25（4）和-25（6）。第1次就诊和第2次就诊时，MCA自基线变化的平均（标准误）最大百分比分别为-49（4）和-48（3），MCA自基线变化的平均（标准误）平均百分比分别为-25（8）和-24（4）。PNIF最大和平均反应的变异系数分别为2.3%和6.5%，MCA分别为7.4%和16.1%。
赖氨酸阿司匹林鼻激发试验后测量PNIF是声反射鼻测量法的一种简单且可重复的替代方法，最大反应比平均反应是更具可重复性的结果指标。
